EASL Clinical Practice Guidelines

Methods

These guidelines were developed by a panel of experts chosen by the European Society of Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). Recommendations were based on evidence from existing papers published before June 2012 and, when evidence was not available, on experts' personal experience. Evidence has been evaluated by the authors and classified as high (A), moderate (B), or low (C) quality according to the Grading of Recommendations Assessment Development and Evaluation (GRADE) system [[54], [55], [56]]. The strength of recommendations (1: strong; 2: weak) reflects the extent to which we can be confident that the desirable effects of the intervention outweigh the undesirable effects, and is based on the balance between desirable and undesirable effects, the quality of underlying evidence, variability in values and preferences and the costs of the intervention (Table 1).

Table 1
Grading of evidence and recommendations according to the GRADE system [54].