Study reveals cells can be reprogrammed to repair severe liver injury

By EASL July 17,2017

A new study has revealed that bile duct cells can switch to become normal liver cells to help repair the liver after severe damage. Understanding how this back-up system is controlled could pave the way for new liver therapies, say the scientists from the Medical Research Council (MRC) Centre for Regenerative Medicine at the University of Edinburgh.The study, published in Nature, investigated hepatocytes, which are the main cell type found in the liver. Hepatocytes play a key role in cleaning toxic substances from the blood stream.

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Article: Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration, Raven et al., Nature, doi: 10.1038/nature23015, published 12 July 2017.