In a new study, a drug originally developed to treat neurological diseases—called URMC-099—protected mice from non-alcoholic fatty liver disease, which is caused by a high-fat diet. Researchers designed the diet they fed the mice to replicate the Western fast food diet and recreate the features of non-alcoholic fatty liver disease found in people. The drug was well tolerated and the research team plans further testing in order to move URMC-099 into early phase human trials...
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Article: Mixed-lineage kinase 3 pharmacological inhibition attenuates murine nonalcoholic steatohepatitis
Kyoko Tomita, Burns C. Blaxall, Samar H. Ibrahim Published August 3, 2017
Citation Information: JCI Insight. 2017;2(15):e94488. doi:10.1172/jci.insight.94488.